Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu
Güncel Gönderiler
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The Biomimetic Synthesis of Polyarylated Fluorenes, Relevant to Selaginellaceae Polyphenols, Leading to the Spontaneous Formation of Stable Radicals
(John Wiley and Sons Inc, 2023)This work reports a biomimetic synthesis of polyarylated fluorene derivatives. The molecules are formed via intramolecular electrophilic aromatic substitution, resembling a cyclization leading towards the natural ... -
Phage-encoded carbohydrate-interacting proteins in the human gut
(Frontiers Media S.A., 2023)In the human gastrointestinal tract, the gut mucosa and the bacterial component of the microbiota interact and modulate each other to accomplish a variety of critical functions. These include digestion aid, maintenance of ... -
Genome-Wide Discovery of Structural Variants Reveals Distinct Variant Dynamics for Two Closely Related Monilinia Species
(Oxford University Press, 2023)Structural variants (SVs) are variants with sizes bigger than 50 bp and capable of changing the size, copy number, location, orientation, and sequence content of genomic DNA. Although these variants have been proven to be ... -
Precarcinogens in food – Mechanism of action, formation of DNA adducts and preventive measures
(Elsevier Ltd, 2023)Food quality and food composition play key roles in human health. Food may contain harmful ingredients apart from the basic ingredients beneficial to our body. A harmful group of substances entering food from the environment ... -
Release of bifidogenic N-glycans from native bovine colostrum proteins by an endo-β-N-acetylglucosaminidase
(Elsevier Inc., 2023)Milk glycoproteins play various biological roles including antibacterial, antiviral activities, modulating immune responses in living organisms. Released N-glycans from milk glycoproteins act as growth substrates for ... -
Synthesis of Selagibenzophenone A and Its Derivatives for Evaluation of Their Antiproliferative, ROR gamma Inverse Agonistic, and Antimicrobial Effect
(John Wiley and Sons Inc, 2023)We report a modular synthetic approach towards novel derivatives of the naturally occurring arylated benzophenone selagibenzophenone A. The initial strategy for the construction of the carbon framework of the derivatives ... -
Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention
(Springer Science and Business Media Deutschland GmbH, 2023)Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drug classes with wide therapeutic applications over the centuries. Starting from the use of salicylate-containing willow leaves to ... -
Internal Transcribed Spacer (ITS) Fails Barcoding of the Genus Neotinea Rchb.f. (Orchidaceae)
(Ankara University, 2021)Internal Transcribed Spacer (ITS) is one of the most used barcoding regions for the molecular phylogenetics and barcoding of orchids. Our aim in this study is to test the reliability of ITS on barcoding of closely related ... -
Pan-Mitogenomics Approach Discovers Diversity and Dynamism in the Prominent Brown Rot Fungal Pathogens
(Frontiers Media S.A., 2021)Monilinia fructicola and Monilinia laxa species are the most destructive and economically devastating fungal plant pathogens causing brown rot disease on stone and pome fruits worldwide. Mitochondrial genomes (mitogenomes) ... -
Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action
(Frontiers Media S.A., 2021)Sexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative ... -
Potential Applications of Endo-beta-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas
(Frontiers Media S.A., 2021)Human milk is the optimal source of infant nutrition. Among many other health benefits, human milk can stimulate the development of a Bifidobacterium-rich microbiome through human milk oligosaccharides (HMOs). In recent ... -
Bovine Colostrum and Its Potential for Human Health and Nutrition
(Frontiers Media S.A., 2021)Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating ... -
Determining Total Protein and Bioactive Protein Concentrations in Bovine Colostrum
(Journal of Visualized Experiments, 2021)Colostrum is a complex biological fluid produced by mammals immediately after parturition. It meets all the nutritional requirements for neonates as a good source of macro-and micronutrients, bioactive peptides, and growth ... -
Recombinant Production of Bifidobacterial Endoglycosidases for N-glycan Release
(Journal of Visualized Experiments, 2021)Protein glycosylation is a diverse and common post-translational modification that has been associated with many important roles such as protein function, including protein folding, stability, enzymatic protection, and ... -
Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols
(Springer, 2022)Morus nigra L. (black mulberry-BM) is a promising nutraceutical fruit containing biologically active polyphenols like anthocyanins, proanthocyanidins, catechins, and stilbenes, with well-established anti-inflammatory, ... -
HA particles as resourceful cancer, steroidal and antibiotic drug delivery device with sustainable and multiple drug release capability
(Taylor & Francis Group, LLC, 2021)Hyaluronic acid (HA) particles with divinyl sulfone (DVS) crosslinking at 10% mole ratio (HA macromolecule repeating units) were prepared and demonstrated as versatile drug carriers with sustainable and long-term release ... -
Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns
(Hindawi Limited, 2021)The genus Diplazium (family: Athyriaceae) comprises approximately 350 species of pteridophytes. Diplazium esculentum (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan ... -
Paving Luteolin Therapeutic Potentialities and Agro-FoodPharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits
(Hindawi, 2021)Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing ... -
A Pharmacological Perspective on Plant‑derived Bioactive Molecules for Epilepsy
(Springer, 2021)Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are ... -
Determination of antioxidant activity and DNA damage protection of marchantia polymorpha L.
(Parlar Scientific Publications, 2021)In this study, the potential biological effects of Maarchantia polymorpha (Bryophyte) from Mount Ida (Crinakkale/Turkey) were investigated. M. polymorpha was extracted using the Soxhlet apparatus with several organic ...
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