• Genetic diversity assessments of brown rot pathogen Monilinia fructicola based on the six simple sequence repeat loci 

  Güven, Hakan; Everhart, Sydney E.; De Miccolis Angelini, Rita Milvia; Özkılınç, Hilal (Springer Science and Business Media Deutschland GmbH, 2021)

  Monilinia fructicola, causal agent of brown rot of stone fruits, is an economically important problem worldwide. Six of the sequence tagged microsatellite sites developed for M. fructicola were used to genotype 68 M. ...

• Phytochemical constituents, biological activities, and health-promoting effects of the genus Origanum 

  Sharifi-Rad, Mehdi; Yılmaz, Yakup Berkay; Antika, Gizem; Salehi, Bahare; Boyuneğmez Tümer, Tuğba (John Wiley and Sons Ltd, 2021)

  Origanum species are mostly distributed around the Mediterranean, Euro-Siberian, and Iran-Siberian regions. Since time immemorial, the genus has popularly been used in Southern Europe, as well as on the American continent ...

• The Biomimetic Synthesis of Polyarylated Fluorenes, Relevant to Selaginellaceae Polyphenols, Leading to the Spontaneous Formation of Stable Radicals 

  Nallappan, Sundaravelu; Lapinskaite, Ringaile; Hajicek, Josef; Kunak, Dominik; Cambal, Peter; B. Tümer, Tuğba (John Wiley and Sons Inc, 2023)

  This work reports a biomimetic synthesis of polyarylated fluorene derivatives. The molecules are formed via intramolecular electrophilic aromatic substitution, resembling a cyclization leading towards the natural ...

• Phage-encoded carbohydrate-interacting proteins in the human gut 

  Rothschild-Rodriguez, Daniela; Hedges, Morgen; Kaplan, Merve; Karav, Sercan; Nobrega, Franklin L. (Frontiers Media S.A., 2023)

  In the human gastrointestinal tract, the gut mucosa and the bacterial component of the microbiota interact and modulate each other to accomplish a variety of critical functions. These include digestion aid, maintenance of ...

• Genome-Wide Discovery of Structural Variants Reveals Distinct Variant Dynamics for Two Closely Related Monilinia Species 

  Durak, Muhammed R.; Özkılınç, Hilal (Oxford University Press, 2023)

  Structural variants (SVs) are variants with sizes bigger than 50 bp and capable of changing the size, copy number, location, orientation, and sequence content of genomic DNA. Although these variants have been proven to be ...

• Precarcinogens in food – Mechanism of action, formation of DNA adducts and preventive measures 

  Bukowska, Bożena; Duchnowicz, Piotr; Boyuneğmez Tümer, Tuğba; Michałowicz, Jaromir; Krokosz, Anita (Elsevier Ltd, 2023)

  Food quality and food composition play key roles in human health. Food may contain harmful ingredients apart from the basic ingredients beneficial to our body. A harmful group of substances entering food from the environment ...

• Release of bifidogenic N-glycans from native bovine colostrum proteins by an endo-β-N-acetylglucosaminidase 

  Bunyatratchata, Apichaya; Parc, Annabelle Le; de Moura Bell, Juliana Maria Leite Nobrega; Cohen, Josh L.; Duman, Hatice; Arslan, Ayşenur; Kaplan, Merve; Barile, Daniela; Karav, Sercan (Elsevier Inc., 2023)

  Milk glycoproteins play various biological roles including antibacterial, antiviral activities, modulating immune responses in living organisms. Released N-glycans from milk glycoproteins act as growth substrates for ...

• Synthesis of Selagibenzophenone A and Its Derivatives for Evaluation of Their Antiproliferative, ROR gamma Inverse Agonistic, and Antimicrobial Effect 

  Lapinskaite, Ringaile; Atalay, Hazal Nazlıcan; Malatinec, Stefan; Dönmez, Serhat; Çınar, Zeynep Özlem; Schwarz, Patrik F. F.; Perhal, Alexander F. F.; Tümer Boyuneğmez, Tuğba (John Wiley and Sons Inc, 2023)

  We report a modular synthetic approach towards novel derivatives of the naturally occurring arylated benzophenone selagibenzophenone A. The initial strategy for the construction of the carbon framework of the derivatives ...

• Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention 

  Özleyen, Adem; Yılmaz, Yakup Berkay; Dönmez, Serhat; Atalay, Hazal Nazlıcan; Antika, Gizem; Boyuneğmez Tümer, Tuğba (Springer Science and Business Media Deutschland GmbH, 2023)

  Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drug classes with wide therapeutic applications over the centuries. Starting from the use of salicylate-containing willow leaves to ...

• Internal Transcribed Spacer (ITS) Fails Barcoding of the Genus Neotinea Rchb.f. (Orchidaceae) 

  Hürkan, Kaan; Taşkın, Kemal Melih (Ankara University, 2021)

  Internal Transcribed Spacer (ITS) is one of the most used barcoding regions for the molecular phylogenetics and barcoding of orchids. Our aim in this study is to test the reliability of ITS on barcoding of closely related ...

• Pan-Mitogenomics Approach Discovers Diversity and Dynamism in the Prominent Brown Rot Fungal Pathogens 

  Yıldız, Gözde; Özkılınç, Hilal (Frontiers Media S.A., 2021)

  Monilinia fructicola and Monilinia laxa species are the most destructive and economically devastating fungal plant pathogens causing brown rot disease on stone and pome fruits worldwide. Mitochondrial genomes (mitogenomes) ...

• Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action 

  Sharifi-Rad, Javad; Quispe, Cristina; Rahavian, Amirhossein; Pereira Carneiro, Joara Nalyda; Rocha, Janaina Esmeraldo; Alves Borges Leal, Antonio Linkoln; Boyuneğmez Tümer, Tuğba (Frontiers Media S.A., 2021)

  Sexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative ...

• Potential Applications of Endo-beta-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas 

  Duman, Hatice; Kaplan, Merve; Arslan, Ayşenur; Şahutoglu, Arif Sercan; Karav, Sercan; Kayılı, Hacı Mehmet; Frese, Steven A. (Frontiers Media S.A., 2021)

  Human milk is the optimal source of infant nutrition. Among many other health benefits, human milk can stimulate the development of a Bifidobacterium-rich microbiome through human milk oligosaccharides (HMOs). In recent ...

• Bovine Colostrum and Its Potential for Human Health and Nutrition 

  Arslan, Ayşenur; Kaplan, Merve; Duman, Hatice; Bayraktar, Ayşe; Karav, Sercan; Ertürk, Melih; Henrick, Bethany M.; Frese, Steven A. (Frontiers Media S.A., 2021)

  Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating ...

• Determining Total Protein and Bioactive Protein Concentrations in Bovine Colostrum 

  Arslan, Ayşenur; Duman, Hatice; Kaplan, Merve; Uzkuç, Hasan; Bayraktar, Ayşe; Erturk, Melih; Alkan, Merve; Karav, Sercan (Journal of Visualized Experiments, 2021)

  Colostrum is a complex biological fluid produced by mammals immediately after parturition. It meets all the nutritional requirements for neonates as a good source of macro-and micronutrients, bioactive peptides, and growth ...

• Recombinant Production of Bifidobacterial Endoglycosidases for N-glycan Release 

  Sucu, Berfin; Bayraktar, Ayşe; Duman, Hatice; Arslan, Ayşenur; Kaplan, Merve; Karyelioğlu, Melda; Ntelitze, Eda; Taştekin, Taner; Yetkin, Seray; Karav, Sercan (Journal of Visualized Experiments, 2021)

  Protein glycosylation is a diverse and common post-translational modification that has been associated with many important roles such as protein function, including protein folding, stability, enzymatic protection, and ...

• Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols 

  Özleyen, Adem; Çınar, Zeynep Özlem; Karav, Sercan; Bayraktar, Ayşe; Arslan, Ayşenur; Kayılı, H. Mehmet; Salih, Bekir; Boyuneğmez Tümer, Tuğba (Springer, 2022)

  Morus nigra L. (black mulberry-BM) is a promising nutraceutical fruit containing biologically active polyphenols like anthocyanins, proanthocyanidins, catechins, and stilbenes, with well-established anti-inflammatory, ...

• HA particles as resourceful cancer, steroidal and antibiotic drug delivery device with sustainable and multiple drug release capability 

  Şahiner, Nurettin; Suner, Selin S.; Kurt, Saliha B.; Can, Mehmet; Ayyala, Ramesh S. (Taylor & Francis Group, LLC, 2021)

  Hyaluronic acid (HA) particles with divinyl sulfone (DVS) crosslinking at 10% mole ratio (HA macromolecule repeating units) were prepared and demonstrated as versatile drug carriers with sustainable and long-term release ...

• Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns 

  Semwal, Prabhakar; Painuli, Sakshi; Painuli, Kartik M.; Antika, Gizem; Boyuneğmez Tümer, Tuğba; Thapliyal, Ashish (Hindawi Limited, 2021)

  The genus Diplazium (family: Athyriaceae) comprises approximately 350 species of pteridophytes. Diplazium esculentum (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan ...

• Paving Luteolin Therapeutic Potentialities and Agro-FoodPharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits 

  Taheri, Yasaman; Sharifi-Rad, Javad; Antika, Gizem; Yılmaz, Yakup Berkay; Boyuneğmez Tümer, Tuğba; Abuhamdah, Sawsan (Hindawi, 2021)

  Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing ...

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