Browsing by Author "Ayyala, Ramesh S."
Now showing items 1-12 of 12
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Biocompatible Glycol Chitosan Microgels as Effective Drug Carriers
Şahiner, Mehtap; Yılmaz, Aynur Sanem; Ayyala, Ramesh S.; Şahiner, Nurettin (MDPI, 2023)Glycol chitosan (GC) is a chitosan (CH) derivative with improved water solubility with regards to CH which affords significant solubility advantages. In this study, microgels of GC as p(GC) were synthesized by a microemulsion ... -
Carbon Tetrafluoride, Oxygen, and Air RF Plasma Modified Low-Density Polyethylene and Polydimethylsiloxane
Polat, Osman; Bhethanabotla, Venkat R.; Ayyala, Ramesh S.; Şahiner, Nurettin (Springer, 2023)Low-density polyethylene (LDPE) and polydimethylsiloxane (silicone or PDMS) were exposed to low-pressure air, oxygen (O2), and carbon tetrafluoride (CF4) plasma to modify their surfaces. Plasma power and irradiation time ... -
Chemically Cross-Linked Poly(β-Cyclodextrin) Particles as Promising Drug Delivery Materials
Demirci, Şahin; Khiev, Dawin; Can, Mehmet; Şahiner, Mehtap; Biswal, Manas R.; Ayyala, Ramesh S.; Şahiner, Nurettin (Amer Chemical Soc, 2021)One-pot synthesis of poly(β-cyclodextrin) (p(β-CD)) micro-/nanoparticles was accomplished using two different cross-linkers, divinyl sulfone (DVS) as p(β-CD)-1 and trimethylolpropane glycidyl ether (TMPGDE) as p(β-CD)-2. ... -
Degradable poly(catechin) nanoparticles as a versatile therapeutic agent
Suner, Selin S.; Sahiner, Mehtap; Mohapatra, Subhra; Ayyala, Ramesh S.; Bhethanabotla, Venkat R.; Sahiner, Nurettin (Taylor and Francis Ltd., 2021)Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 +/- 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 degrees ... -
HA particles as resourceful cancer, steroidal and antibiotic drug delivery device with sustainable and multiple drug release capability
Şahiner, Nurettin; Suner, Selin S.; Kurt, Saliha B.; Can, Mehmet; Ayyala, Ramesh S. (Taylor & Francis Group, LLC, 2021)Hyaluronic acid (HA) particles with divinyl sulfone (DVS) crosslinking at 10% mole ratio (HA macromolecule repeating units) were prepared and demonstrated as versatile drug carriers with sustainable and long-term release ... -
Low-pressure plasma treated polycarbonate and polymethyl methacrylate (PMMA) sheets with different surface patterns to change their surface properties
Gizer, S. Görkem; Bhethanabotla, Venkat R.; Ayyala, Ramesh S.; Şahiner, Nurettin (Elsevier B.V., 2023)Low-pressure plasmas of carbon tetrafluoride (CF4), oxygen (O2), and air were used to treat the surfaces of polycarbonate (PC) and polymethyl methacrylate (PMMA) to achieve a variety of surface attributes, such as ... -
Physically Crosslinked Chondroitin Sulfate (CS)-Metal Ion (M: Fe(III), Gd(III), Zn(II), and Cu(II)) Particles for Versatile Applications and Their Biosafety
Sağbaş Suner, Selin; Şahiner, Mehtap; Umut, Evrim; Ayyala, Ramesh S.; Şahiner, Nurettin (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Chondroitin sulfate (CS), a well-known glycosaminoglycan, was physically crosslinked with Fe(III), Gd(III), Zn(II), and Cu(II) ions to obtain CS-Fe(III), CS-Gd(III), CS-Zn(II), and CS-Cu(II) polymeric particles for ... -
Poly(Glycerol) Microparticles as Drug Delivery Vehicle for Biomedical Use
Şahiner, Mehtap; Yılmaz, Aynur Sanem; Ayyala, Ramesh S.; Şahiner, Nurettin (MDPI, 2023)Glycerol (Gly) is a well-known, FDA-approved molecule posing three hydroxyl groups. Since Gly is biocompatible, here, it was aimed to prepare poly(Glycerol) (p(Gly)) particles directly for the first time for the delivery ... -
A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles
Sağbaş Suner, Selin; Mohapatra, Subhra; Ayyala, Ramesh S.; Brethanabotla, Venkat R.; Şahiner, Nurettin (Wiley, 2021)Catechin (CAT) was crosslinked with trimethylolpropane triglycidyl ether(TMPTGE) to obtain degradable poly(CAT) particles in a single step. Sphericalp(CAT) particles with tens of micrometer size range and an isoelectronic ... -
Synthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system
Şahiner, Mehtap; Güngör, Buket; Sılan, Coşkun; Demirci, Şahin; Erdoğan, Hakika; Ayyala, Ramesh S.; Şahiner, Nurettin (Elsevier B.V., 2024)Microgels of maltodextrin (MDex) as poly(maltodextrin) (p(MDex)) were prepared by reverse-micelle crosslinking technique at various crosslinking ratios, 25, 50, and 100% based on the repeating unit of MDex using divinylsulfone ... -
Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti‑biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities
Sağbaş Suner, Selin; Şahiner, Mehtap; Ayyala, Ramesh S.; Bhethanabotla, Venkat R.; Şahiner, Nurettin (Springer, 2021)Nanostructured fuorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The precursors citric acid (CA) and cysteine (Cys) were used in the preparation ... -
Versatile poly(maltose) micro/nanoparticles with tunable surface functionality as a biomaterial
Kurt, Saliha B.; Ayyala, Ramesh S.; Şahiner, Nurettin (John Wiley and Sons Inc, 2021)Maltose, a natural disaccharide, was crosslinked with divinyl sulfone to prepare poly(maltose) (p(MAL)) micro/nanoparticles via one step microemulsion system with ≥90% ± 5% yield in a size rage of 0.5–100 μm for the first ...
