Browsing by Author "Şahiner, Mehtap"
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Biocompatible Glycol Chitosan Microgels as Effective Drug Carriers
Şahiner, Mehtap; Yılmaz, Aynur Sanem; Ayyala, Ramesh S.; Şahiner, Nurettin (MDPI, 2023)Glycol chitosan (GC) is a chitosan (CH) derivative with improved water solubility with regards to CH which affords significant solubility advantages. In this study, microgels of GC as p(GC) were synthesized by a microemulsion ... -
Biodiverse Properties of Tannic Acid-Based Fibers
Şahiner, Mehtap; Kurt, Saliha B.; Şahiner, Nurettin (Springer, 2021)Tannic acid (TA) is a plant-based polyphenolic molecule with enticing anti-oxidant, anti-bacterial, antiinflammatory and anti-cancer features, making it a valuable material in bio-medicinal applications. To establish whether ... -
Cell Staining Microgels Derived from a Natural Phenolic Dye: Hematoxylin Has Intriguing Biomedical Potential
Şahiner, Mehtap; Sunol, Aydin K.; Şahiner, Nurettin (Multidisciplinary Digital Publishing Institute (MDPI), 2024)Hematoxylin (HT) as a natural phenolic dye compound is generally used together with eosin (E) dye as H&E in the histological staining of tissues. Here, we report for the first time the polymeric particle preparation from ... -
Chemically Cross-Linked Poly(β-Cyclodextrin) Particles as Promising Drug Delivery Materials
Demirci, Şahin; Khiev, Dawin; Can, Mehmet; Şahiner, Mehtap; Biswal, Manas R.; Ayyala, Ramesh S.; Şahiner, Nurettin (Amer Chemical Soc, 2021)One-pot synthesis of poly(β-cyclodextrin) (p(β-CD)) micro-/nanoparticles was accomplished using two different cross-linkers, divinyl sulfone (DVS) as p(β-CD)-1 and trimethylolpropane glycidyl ether (TMPGDE) as p(β-CD)-2. ... -
Chondroitin Sulfate-Based Cryogels for Biomedical Applications
Demirci, Şahin; Şahiner, Mehtap; Ari, Betül; Sunol, Aydın K.; Şahiner, Nurettin (MDPI, 2021)Cryogels attained from natural materials offer exceptional properties in applications such as tissue engineering. Moreover, Halloysite Nanotubes (HNT) at 1:0.5 weight ratio were embedded into CS cryogels to render additional ... -
Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
Demirci, Şahin; Şahiner, Mehtap; Sağbaş Suner, Selin; Şahiner, Nurettin (MDPI, 2021)Carbon nanotubes (CNTs) due to their outstanding mechanical, thermal, chemical, and optical properties were utilized as a base material and were coated with polydopamine (PDA) (PDA@CNT) via the simple self-polymerization ... -
Physically and Chemically Crosslinked, Tannic Acid Embedded Linear PEI-Based Hydrogels and Cryogels with Natural Antibacterial and Antioxidant Properties
Şahiner, Mehtap; Yılmaz, Aynur Sanem; Demirci, Şahin; Şahiner, Nurettin (MDPI, 2023)Linear polyethyleneimine (L-PEI) was obtained from the acidic hydrolysis of poly(2-ethyl-2-oxazoline) and employed in the synthesis of physically crosslinked L-PEI hydrogel, PC-L-PEIH, chemically crosslinked L-PEI hydrogel, ... -
Physically Crosslinked Chondroitin Sulfate (CS)-Metal Ion (M: Fe(III), Gd(III), Zn(II), and Cu(II)) Particles for Versatile Applications and Their Biosafety
Sağbaş Suner, Selin; Şahiner, Mehtap; Umut, Evrim; Ayyala, Ramesh S.; Şahiner, Nurettin (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Chondroitin sulfate (CS), a well-known glycosaminoglycan, was physically crosslinked with Fe(III), Gd(III), Zn(II), and Cu(II) ions to obtain CS-Fe(III), CS-Gd(III), CS-Zn(II), and CS-Cu(II) polymeric particles for ... -
Poly(Glycerol) Microparticles as Drug Delivery Vehicle for Biomedical Use
Şahiner, Mehtap; Yılmaz, Aynur Sanem; Ayyala, Ramesh S.; Şahiner, Nurettin (MDPI, 2023)Glycerol (Gly) is a well-known, FDA-approved molecule posing three hydroxyl groups. Since Gly is biocompatible, here, it was aimed to prepare poly(Glycerol) (p(Gly)) particles directly for the first time for the delivery ... -
Poly(vinyl alcohol)-tannic Acid Cryogel Matrix as Antioxidant and Antibacterial Material
Arı, Betül; Şahiner, Mehtap; Demirci, Şahin; Şahiner, Nurettin (MDPI (Multidisciplinary Digital Publishing Institute), 2022)The biocompatible, viscoelastic properties of poly(vinyl alcohol) (PVA) in combination with the antimicrobial and antioxidant natural polyphenolic, tannic acid (TA), and the natural flavonoid and antioxidant curcumin ... -
Poly(Vinylamine) Derived N-Doped C-Dots with Antimicrobial and Antibiofilm Activities
Sutekin, Semiha Duygu; Şahiner, Mehtap; Suner, Selin Sağbaş; Demirci, Şahin; Güven, Olgun; Şahiner, Nurettin (MDPI (Multidisciplinary Digital Publishing Institute), 2021)Nitrogen-doped carbon dots (N-doped C-dots) was synthesized by using poly(vinyl amine) (PVAm) as a nitrogen source and citric acid (CA) as a carbon source via the hydrothermal method. Various weight ratios of CA and PVAm ... -
Quercetin particles with lower inhibitory activity for α-glucosidase and negligible effects on blood clotting
Şahiner, Mehtap; Suner, Selin Sağbaş (Turkish Chemical Society, 2021)Poly(quercetin) (p(QR)) particles were synthesized by using poly (ethylene glycol) diglycidyl ether (PEGGE) crosslinker in a single step via a microemulsion system. The morphological, size, and functional analysis of the ... -
A Review on Phyto-Therapeutic Approaches in Alzheimer's Disease
Şahiner, Mehtap; Yılmaz, Aynur Sanem; Güngör, Buket; Şahiner, Nurettin (MDPI, 2023)Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases. ... -
Rod-like L-Aspartic acid-Cu(II) metal organic frameworks; Synthesis, characterization and biomedical properties
Gizer, Görkem; Şahiner, Mehtap; Yıldırım, Yıldız; Demirci, Şahin; Can, Mehmet; Şahiner, Nurettin (Elsevier B.V., 2021)L-aspartic acid (L-AA) based MOFs were prepared from acetate, chloride, nitrate, and sulfate salts of Cu(II) ions as L-AA-Cu(II)-A,-C,-N,-S, respectively with 96.7 2.4, 89.8 3.1, 92.1 1.5, 74.6 5.2 m2/g, surface ... -
Synthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system
Şahiner, Mehtap; Güngör, Buket; Sılan, Coşkun; Demirci, Şahin; Erdoğan, Hakika; Ayyala, Ramesh S.; Şahiner, Nurettin (Elsevier B.V., 2024)Microgels of maltodextrin (MDex) as poly(maltodextrin) (p(MDex)) were prepared by reverse-micelle crosslinking technique at various crosslinking ratios, 25, 50, and 100% based on the repeating unit of MDex using divinylsulfone ... -
Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti‑biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities
Sağbaş Suner, Selin; Şahiner, Mehtap; Ayyala, Ramesh S.; Bhethanabotla, Venkat R.; Şahiner, Nurettin (Springer, 2021)Nanostructured fuorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The precursors citric acid (CA) and cysteine (Cys) were used in the preparation ...
